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| To
face the trend of biochemical technology,
we devote ourselves to develop the following
products: |
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| Function
and Indication: |
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| Compound
Fluorouracil Injection , the targeting-carrier
of anti-tumor injection, directly targets
on the tumors. It won't influence the amount
of leukocyte. Applied to malignant tumors
of alimentary tract, hepatoma lung cancer,
lymphosarcoma, mammary cancer, bladder cancer,
uterus cancer, prostate cancer and cancer
of the urinary tract, etc. |
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liposomal oleatis-5fu
(Compound Fluorouracil Injection)
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| Main
Ingredients |
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The
injection whose volume is 10 ml
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5-fluorouracil (5-FU), oleatis, soybear lecithin,
cholesterol and ginseng polysaccharide. |
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<TOP>
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| Mechanism |
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A
series of animal experiment and clinical
treatment proved that it does not only facilitate
the immunity (to remarkably promote the
phagocytosis of the phagocyte) but also
surely kills cancer cells.
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According
to lots of basic research and the clinical
reports, we can prove this dosage can kill
cancer cell by following proofs:
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The
5-FU in the liposome, which can inhibit
several of animal tumors and the
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of thymine and it also effect on RNA and the
hyperplastic cells, is a kind of pyrimidine
cytarabine. Then it can be the first and normal
medication of gastrointestinal tract.
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2.
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Anti-tumor
capability of Oleatiss：
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Oleatis in this injection is comprised
of so-called unsaturated fatty
acids, including oleic acids,linolenic
acids and arachidonic acids, etc.The
amount of unsaturated fatty acids is diminished
in the tissues of animals having cancers.Organism
must use these necessary fatty acids to
synthesize phospholipids (lecithin).Phospholipids
are an important component of cellular structures,
especially in the mitochondria.The insufficiency
or over oxidation will cause the changes
of mitochondria structure or transformation,
even death.Besides, phospholipid is also
the precursor of postaglanging(PG). It is
well known that PG possess a anti-tumor
ability and cancer cells can be reverted
back to normal after PG treatment.
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3.
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Physiological
Function of Phospholipids：
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lecithin possesses versatile physiological
functions It can increase the number of macrophages
and invigorate the phagocytosis of macrophages.
Moreover, phospholipids and cholesterol form
a bimolecular layer. |
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4.
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Physiological
Function of Cholesterol：
Cholesterol, with certain anti-cancer function,
constitute a lipid bilayer together with
phospholipids. Leukocyte, a type of white
blood cells in human blood, secretes leukin
to injure and phagocytize the metamorphosis
cells (cancer cells) in order to remove
the activity of cancer cells.If there is
low cholesterol in the blood, the ability
of leukocyte secreting leukin will be descended.So,
increasing cholesterol appropriately will
enhance anti-cancer ability.
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5.
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The
anti-tumor theory of ginseng polysaccharide：
The major function is enhancing the immunization
of organism. It inhibits animal metastasis.
Ginseng polysaccharide also stimulates the
generation of complements and antibodies
and increases the content of immune globulin
in the blood.
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<TOP>
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| Research
of
liposome in
cytodyanmics. |
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1.
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The effect of 3H-TdR to the synthesis of
DNA in the liver cancer cell: |
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Dealing liver cancer cells with the same concentration
(1mg/ml) Liposome, we estimate the 3H-TdR in the
liver cells in different time. Besides, we also
count the inhibition rate of 3H-TdR on the synthesis
of DNA. The result indicates: 94.9% inhibition rate
in 0.5 hour, P<0.02; 99.7% inhibition rate, P<0.02,
in one hour; 98.2% inhibition rate in 2 hours, P<0.001;
98.3% inhibition rate in 4 hours, P<0.05. |
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The effect of 3H-TdR to the synthesis of
RNA in the hydroabdomen liver cancer cells. |
Treating
by the same conc. (1mg/ml) liposome, we estimate
the CPm value in different time, and also count
the inhibition potency of liposome on the synthesis
of DNA.
The result indicates that:
98.9% inhibition rate, P<0.02, in 0.5 hour;
97.8% inhibition rate, P<0.001, in 1 hour;
98.98% inhibition rate in 2 hours, P<0.001;
98.8% inhibition rate in 4 hours, P<0.001;
These experiments indicate that:
There is significant inhibition potency in the synthesis
of DNA dealing with the liver cancer cells and the
hydrobdomen liver cancer cells. Both the curve of
3H-TdR value into cells is slowly increasing. The
intensity is more stable after working two hours.
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The Effect of 3H-TdR to the Synthesis of
RNA in the Liver Cancer Cells: |
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result indicates that the medicine (1mg/ml) working
on the syntheses of RNA in the liver cancer cells
has an inhibition rate, 97.4%, P<0.01, in 2 hours.
When increasing the concentration. Of drug (10mg/ml),
the inhibition is 97.4%, P<0.001. That indicates
that there is no significant conc. Effect on the
inhibition rate. |
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<TOP>
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| The
Relation of The Liposome Targeting System and The
Phagocytosis of The Phagocyte |
| Liposome,
a targeting delivery system of anti-tumor drug preparation,
is a kind of missile- like ultra-particle medicine
carrier. It can transport the anti-tumor drug to
the target (the cancer or its metastasis), and makes
the concentration of the drug in the target area.
The main course of targeting system is the phagocytosis
and the integration of the phagocyte to the ultra-particle
carrier. There are some other courses of targeting
system. One of them is the adsorption of the lipid
surface and the cancer. The other one is the lipid
transfer on the surface of the lipid and the cancer.
However, the most important route of this system
is the interaction between the phagocytosis of phagocyte
and the generation and the inhibition of cancer.
Although the phagocytosis is a nonspecific immunity,
it can inactivate the cancer and eliminate the free
cancer-cells in addition to inhibit the generation
or the extension of the carcinoma. |
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<TOP>
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E-Maill：lipo@liposomal.org